Bupropion (Wellbutrin)

Bupropion is different in the world of antidepressant medications because it works much like an amphetamine. Bupropion suppresses the appetite with stimulant effects like amphetamines do. It takes 1 to 3 weeks for antidepressant effects to occur and the effects are much like that of amitriptyline, an antidepressant tricyclic.

It is believed that Bupropion works by blockading dopamine uptake but the mechanism that relieves depression is unknown. This drug does not affect serotonin, cholinergic, or histamine transmission.

Unlike SSRIs Bupropion apparently does not cause weight gain or sexual problems. It actually does quite the opposite, appearing to increase sexual desire and pleasure. Because of this it can be used to counter the effects of sexual dysfunction caused by SSRIs and it is also used to increase sexual interest in women with hypoactive sexual desire disorder. This drug can also be used as an aid to help people stop smoking.

For patients who have a hard time tolerating the side effects of SSRIs Bupropion is a good alternative because of its lack of side effects. Seizures are the most serious side effect and can occur if the dose taken is too high. Aside from seizures Bupropion can also cause agitation, headaches, constipation, dry mouth, weight loss, dizziness, upset digestive system, tremors, insomnia, blurred vision, and tachycardia.

Doses above 450 mg/day should be avoided because dosages above this amount can produce seizures. People with pre-existing conditions such as head trauma, pre-existing seizure disorders, central nervous system tumors, and the use of other drugs that lower the seizure threshold are at a greater risk of experiencing seizures.

People who may potentially be Bupropion users should also know that MAOIs are known to increase its toxicity and should therefore discontinue use of MAOIs at least two weeks before starting Bupropion treatment.